The round, which brings the total funds raised by the company so far to $46.5m, was also backed by former executive of Cisco Don Listwin.
The previous funding round took place in December 2010.
San Francisco-based Clustrix intends to use the funding to expand distribution of its software to various public and private cloud platforms.
USVP partner Chris Rust said, “Clustrix has delivered on a complete reinvention of the relational database.
“The result is a highly differentiated platform that is ideal for the industry transition to cloud computing.
“The company now has the proven technology, experienced management, and customer traction to disrupt a $30bn dollar market.”
Since its launch in 1981 USVP has invested more than $2.7bn in more than 450 companies. The firm has recently led a $15m funding round for online social commenting platform Livefyre.
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